In this episode of Heart Failure Beat, guest editors Drs. Susanna Mak, Daniel Burkhoff, and Mark Belkin discuss the November Journal of Cardiac Failure November 2025 focus issue on Hemodynamics. They explored how a renewed understanding of pressure-volume loops, exercise testing, and hemodynamic phenotyping can reshape heart failure diagnosis and management. They also shared highlights from the issue, from patient perspectives on invasive procedures to early-career reflections and the continuing debate over ECMO unloading versus loading.Guest names and titles: