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Heart failure with mildly reduced ejection fraction (HFmrEF) affects up to one in four patients with heart failure, yet it remains one of the most misunderstood and under-discussed phenotypes in clinical practice. In this episode of Heart Failure Beat, hosts Michael Beasley, MD, and Priya Umapathi, MD, sit down with Jane E. Wilcox, MD, and Barry A. Borlaug, MD, co-lead authors of the newly published HFSA Scientific Statement: Heart Failure with Mildly Reduced Ejection Fraction, to discuss why this patient population deserves greater attention.

The conversation explores how HFmrEF fits between HFrEF and HFpEF, why ejection fraction alone may not tell the whole story, practical treatment considerations, and the important concept of HFmrEF as both an overlap and transitional state.

Read the Scientific Statement: HFSA Scientific Statement: Heart Failure with Mildly Reduced Ejection Fraction

Published in the June 2026 issue of the Journal of Cardiac Failure.