Sharon HF Seminar Practice-1-01 24 HF SEM - ADVANCE HF

01 24 HF SEM - ADVANCE HF - Schroder

Pdf Summary

The document discusses advancements in heart transplant procedures focusing on organ recovery, preservation, and perfusion techniques. It highlights the use of innovative technologies like the Paragonix SherpaPak Cardiac Transport System and Transmedics Organ Care System (OCS) compared to traditional methods like ice storage. The SherpaPak system is shown to improve post-transplant outcomes by maintaining controlled hypothermia and isolating the heart from external pressures. Data presented at ISHT 2024 suggests significant reductions in primary graft dysfunction (PGD) with optimal pressure and temperature conditions using SherpaPak compared to ice storage.<br /><br />The XVIVO system, particularly in the PRESERVE trial, demonstrates the importance of machine perfusion in enhancing outcomes for Extended Criteria Donors (ECD) and Donation after Circulatory Death (DCD) donors. The study emphasizes the significance of temperature control during organ preservation and the need for more research in this field. Results from the US DCD Trial show improved patient and graft survival rates through 2 years post-transplant with the use of the OCS compared to the control group.<br /><br />In conclusion, the document underscores the evolution in heart transplant techniques away from traditional ice storage methods and towards advanced preservation and perfusion technologies. It stresses the importance of temperature control and the benefits of machine perfusion in enhancing outcomes for different donor populations. The need for further research and standardization in reporting methods is highlighted to continue improving heart transplant success rates.

Keywords

heart transplant procedures

organ recovery

preservation techniques

perfusion techniques

Paragonix SherpaPak Cardiac Transport System

Transmedics Organ Care System

controlled hypothermia

primary graft dysfunction

machine perfusion

extended criteria donors