CardioBites Plus: Amyloidosis - Mechanism of Disease-CardioBites Plus: Amyloidosis

CardioBites Plus: Amyloidosis - Mechanism of Disease2

Video Transcription

Video Summary

In this episode of CardioBytes Plus, Dr. Justin Grodin and Dr. Jobin Vaishnav discuss amyloidosis, particularly its mechanisms, impact on the heart, and the differences between AL and ATTR types. Amyloidosis involves misfolded proteins forming amyloid fibrils, which disrupt normal tissue architecture and lead to organ dysfunction. The conversation highlights the heterogeneity in disease presentation and progression, even within subtypes, and explores hypotheses on early onset in younger patients and factors influencing the penetrance of hereditary ATTR. Both share insights on challenges in diagnosis and treatment adaptability.

Keywords

amyloidosis

cardiac impact

AL and ATTR types

protein misfolding

diagnosis challenges