Board Certification Review 2023 Spotlight: Cardiac Transplantation-Rejection: Cellular and Antibody Mediated

Rejection: Cellular and Antibody Mediated

Video Transcription

Video Summary

The video lecture discusses rejection in organ transplantation, focusing on heart transplants. The lecturer begins by explaining the epidemiology of rejection, stating that about one in four heart transplant recipients will experience at least one episode of rejection within the first year, but only 12-15% will require treatment. The incidence of treated rejection has decreased over the years due to changes in immune suppression. Factors associated with higher rates of rejection include young age, African American race, female gender, and allosensitization. The lecturer emphasizes that while rejection is important to pay attention to, it is not the most common cause of graft loss or death. Infection, graft failure, and multi-organ failure are more common causes. The lecturer then discusses the detection of rejection, which includes considering symptoms such as fatigue, overt heart failure, or cardiogenic shock, as well as using tests like EKG, echocardiogram, and endomyocardial biopsy. They note that the biopsy is the gold standard, but it is invasive and can have inter-observer variability in interpretation. The lecture also highlights non-invasive tests for rejection that have shown some success, such as gene expression profiling and cell-free DNA testing. The lecturer concludes by discussing the different types of rejection, cellular rejection, and antibody-mediated rejection, and the treatment strategies for each. The lecture provides valuable information on the epidemiology, detection, and management of rejection in heart transplantation.

Meta Tag

Rejection: Cellular and Antibody Mediated vasopressors

Rejection: Cellular and Antibody Mediated tacrolimus

Rejection: Cellular and Antibody Mediated methylprednisolone

Rejection: Cellular and Antibody Mediated basiliximab

Rejection: Cellular and Antibody Mediated thymoglobulin

Rejection: Cellular and Antibody Mediated methotrexate

Rejection: Cellular and Antibody Mediated brain natriuretic peptide

Rejection: Cellular and Antibody Mediated BNP

Rejection: Cellular and Antibody Mediated troponin

Rejection: Cellular and Antibody Mediated C-reative protein

Rejection: Cellular and Antibody Mediated CRP

Rejection: Cellular and Antibody Mediated ventricular evoked potentials

Rejection: Cellular and Antibody Mediated VER

Rejection: Cellular and Antibody Mediated allomap

Rejection: Cellular and Antibody Mediated inotropes

Rejection: Cellular and Antibody Mediated immune apheresis

Rejection: Cellular and Antibody Mediated cytolytic

Rejection: Cellular and Antibody Mediated H&E

Rejection: Cellular and Antibody Mediated pAMR

Rejection: Cellular and Antibody Mediated AMR therapies

Rejection: Cellular and Antibody Mediated ACR

Rejection: Cellular and Antibody Mediated histology

Rejection: Cellular and Antibody Mediated D-OAR

Rejection: Cellular and Antibody Mediated dd-cfDNA

Rejection: Cellular and Antibody Mediated cfDNA

Rejection: Cellular and Antibody Mediated DNA

Rejection: Cellular and Antibody Mediated gene expression

Rejection: Cellular and Antibody Mediated right ventricular endomyocardial

Rejection: Cellular and Antibody Mediated allograft

Rejection: Cellular and Antibody Mediated rituximab

Rejection: Cellular and Antibody Mediated plasmapheresis

Rejection: Cellular and Antibody Mediated IVIG

Rejection: Cellular and Antibody Mediated gene

Rejection: Cellular and Antibody Mediated endomyocardial

Rejection: Cellular and Antibody Mediated humoral rejection

Rejection: Cellular and Antibody Mediated cellular rejection

Rejection: Cellular and Antibody Mediated screening techniques

Rejection: Cellular and Antibody Mediated epidemiology

Keywords

organ transplantation

rejection

heart transplants

epidemiology

immune suppression

graft loss

death